| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Mantel-Teeuwisse, A.K. | |
| dc.contributor.author | Petkoska, Irena | |
| dc.date.accessioned | 2024-01-01T01:02:05Z | |
| dc.date.available | 2024-01-01T01:02:05Z | |
| dc.date.issued | 2024 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/45727 | |
| dc.description.abstract | This study reveals the frequency, nature, and severity of the self-reported side effects of a low-dose amitriptyline and
mirtazapine in comparison to placebo. It is assumed that in the future these results in addition to the results of effectiveness will facilitate the selection process for the most appropriate hypnotic for patients. More specifically, the
results of this study may help, support, and facilitate the decision-making in general practice for use of mirtazapine
and amitriptyline as off-label treatment of insomnia. Our study indicates that the patients in the mirtazapine arm
in week 6 reported statistically more significant attributed SEs than those in the placebo arm. Increased occurrence of
attributed SEs in the amitriptyline arm was not significant compared to the placebo arm. As estimated with the GEE
model these differences decreased after 12 weeks of treatment. | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | The DREAMING study was a randomized, double-blind, placebo-controlled, phase III trial with three treatment groups. The primary study outcome was the difference in the occurrence of the SEs attributed to the use of the study medicines in comparison to placebo. The secondary outcomes were the nature and severity of the patients’ self reported side effects of a low dose of mirtazapine (7.5-15mg) and amitriptyline (10-20mg) in patients with insomnia compared to placebo. | |
| dc.title | Side effects of low-dose mirtazapine and amitriptyline in patients with insomnia: a randomized, double-blind, placebocontrolled trial | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Farmacie | |
| dc.thesis.id | 13010 | |
