dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Heesters, B.A. | |
dc.contributor.author | Graaf, Pip de | |
dc.date.accessioned | 2023-10-15T23:00:56Z | |
dc.date.available | 2023-10-15T23:00:56Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/45376 | |
dc.description.abstract | The semi-random generation of lymphocyte receptor binding domains through V(D)J recombination creates a vast repertoire of receptors to combat pathogens. Establishing tolerance towards these receptors requires an equally vast repertoire of self-antigens. How is this repertoire established and what is its impact on the negative selection process? This review attempts to create an overview of self-antigen repertoires in the humoral immune system, with a focus towards B cell receptors and T-cell receptors. It establishes the possible roles and mechanisms of tissue restricted antigen regulators like AIRE, as well as the role of B-1 cells in this process. It also includes a brief overview of peripheral tolerance and its impact in this context. The final conclusion is that tolerance towards T-cell receptors seems incomplete, but the lack of relevant diseases indicates an as of yet undiscovered T-cell receptor repertoire. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | V(D)J recombination creates semi-random domains that are difficult to establish tolerance against. This review explores the currently known avenues of tolerance towards TCR and BCR binding domains and concludes that the current literature does not contain a complete mechanism of TCR tolerance. | |
dc.title | Immunological tolerance for the diverse antigen binding domains of B cell and T cell receptors | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | T cell receptor; B cell receptor; central tolerance; peripheral tolerance; vdj recombination; immunology; b-1 cell; b-2 cell; b cell; b-1a cell; b-1b cell; t cell; mtec; medullary thymic epithelial cell; antigen repertoire; AIRE; adaptive tolerance; IgM; IgD; Fezf2; | |
dc.subject.courseuu | Drug Innovation | |
dc.thesis.id | 25241 | |