| dc.description.abstract | The planetary health diet (PHD) recommends to limit the intake of animal sourced
foods and starchy vegetables and recommends high intake of plant-based foods. Adherence to the
PHD has been associated with a lower risk of cardiovascular diseases (CVDs). However, the
underlying biological mechanism of this relation is unknown. In our study we develop a
metabolomic signature based on the PHD-score of participants, and
investigate whether this metabolomic signature is associated with CVD.
Data of 4088 participants (mean age 55.6 (9.90), 48.0% men (n= 1963)) from the
Doetinchem Cohort study were used. The PHD-score was assessed using a validated food
frequency questionnaire (FFQ). Metabolites were measured at the Nightingale platform, Finland.
Least absolute shrinkage and selection operator (LASSO) was used to identify the metabolomic
signature (round 4, R4) based on the PHD-score (R4). Cox regression analyses were used to
examine association between the identified metabolomic signature and 10-year incidence CVD (R5-
6).
We identified a metabolomic signature, comprised of 45 metabolites. The signature
consisted mainly of relative lipoprotein concentrations, but also fatty acids, amino acids, ketone
bodies, glycolysis related metabolites, metabolites involved in fluid balance, lipoprotein subclasses,
other lipids, and metabolites involved in inflammation. In Cox regressions, the metabolomic
signature showed a borderline significant association with CVD incidence after adjustment for age,
sex, educational level, and lifestyle factors (smoking, alcohol consumption, and physical activity)
[HR = 0.851 (95% CI: 0.704 – 1.029)].
We identified a metabolomic signature which reflects the adherence to the Planetary
Health Diet. In Cox regression the metabolomic signature showed borderline significance after
adjustment for age, sex, educational level, and lifestyle factors (smoking, alcohol consumption,
and physical activity). | |
