| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Doorn, J. van | |
| dc.contributor.author | Kort, R.A.L. de | |
| dc.date.accessioned | 2010-03-29T17:00:13Z | |
| dc.date.available | 2010-03-29 | |
| dc.date.available | 2010-03-29T17:00:13Z | |
| dc.date.issued | 2010 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/4480 | |
| dc.description.abstract | The Insulin-Like Growth Factor (IGF) system is involved in the regulation of cell growth, differentiation and sustains survival in several tissues. The Insulin-Like Growth Factor Binding Proteins (IGFBPs) are a family of six proteins with high-affinity for IGFs that comprise an important part of the IGF system. IGFBPs have been demonstrated to modulate IGF bioactivity in a spatiotemporal way. This effect on IGF actions can both be stimulatory and inhibitory. More recently, IGF-independent effects of IGFBPs have been revealed that play important roles in tumor cell growth and progression. IGFBP-2 is the second most abundant IGFBP in circulation and its expression pattern has been shown to be altered in many pathological conditions. This review focuses on the biological role of IGFBP-2 in tumorigenesis and metabolic homeostasis. | |
| dc.description.sponsorship | Utrecht University | |
| dc.format.extent | 961957 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | |
| dc.title | The Biological Role of Insulin-Like Growth Factor binding Protein-2 in Tumorigenesis and Metabolic Homeostasis | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | Insulin-Like Growth Factor system, Insulin-Like Growth Factor Binding Protein-2, Tumorigenesis, Metabolic Homeostasis, IGF-dependent effects, IGF-independent effects | |
| dc.subject.courseuu | Biology of Disease | |
