| dc.description.abstract | Introduction. Prostate cancer requires a faster diagnostic pathway due to the long time to diagnosis and patient anxiety. To address this issue, a quick diagnostic route <36 hours was implemented. Previous research highlighted lower urinary tract symptoms as a protective factor for prostate biopsies. Therefore, our study aims to individualize the fast-track by exploring the association between the International Prostate Symptom Score and deviant magnetic resonance imaging scans.
Methods. Retrospective single-center cohort study, aiming to associate the International Prostate Symptom Score with abnormal magnetic resonance scans in men who had undergone the prostate cancer fast-track. Male patients participated from July 2022 to March 2023 at St. Antonius Hospital Nieuwegein. Primary outcome: abnormal magnetic resonance imaging scan, secondary outcomes: biopsy rates, prostate cancer diagnosis. Group 1: PI-RADS score 1-2 scans, group 2: PI-RADS score 3-5 scans. Univariate and multivariate logistic regression analyses were used.
Results. 268 men were enrolled. Multivariate analysis showed significant associations between magnetic resonance imaging scan abnormalities and International Prostate Symptom Score (OR 0.952 [0.908-0.997]; p 0.036), IPSS mild vs. severe (OR 3.844 [1.236- 11.952], p 0.020), IPSS severe vs. mild (OR 0.260 [0.084-0.809]; p 0.020, irritative LUTS at referral (OR 0.420 [0.186-0.946]; p 0.036) and LUTS presence (OR 0.549 [0.304-0.989]; p 0.046).
Discussion. Based on our findings, upon confirmation though a prospective study, it appears that in the future, men with a mild IPSS score should consistently be placed in the fast-track, while men exhibiting irritative lower urinary tract symptoms should not. | |
