Expression of the Steroidogenic Enzymes CYP11A1, 3β-HSD and CYP21 in Canine Cortisol-secreting Adrenocortical Tumors and Healthy Adrenals

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Galac, S.
dc.contributor.author	Heiligenberg, M.M. van den
dc.date.accessioned	2010-03-23T18:00:51Z
dc.date.available	2010-03-23
dc.date.available	2010-03-23T18:00:51Z
dc.date.issued	2010
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/4447
dc.description.abstract	Cortisol producing adrenocortical tumors (AT) present clinicians with a challenge. The tumors reduce the life expectancy of the dogs and are difficult to treat. In this study, tests were performed to find out whether there is any significant difference in the expression of steroidogenic enzymes CYP11A1, 3β-HSD and CYP21 between adrenocortical adenomas (ACA), adrenocortical carcinomas (ACC) and healthy adrenal tissue. It was found that there was no significant difference in the expression profiles of CYP11A1 and CYP21 between adrenocortical adenomas, carcinomas and healthy adrenal tissue. There was a 1,80 fold increase in the expression of 3β-HSD in adenomas when compared to healthy adrenal tissue.
dc.description.sponsorship	Utrecht University
dc.format.extent	892416 bytes
dc.format.mimetype	application/msword
dc.language.iso	en
dc.title	Expression of the Steroidogenic Enzymes CYP11A1, 3β-HSD and CYP21 in Canine Cortisol-secreting Adrenocortical Tumors and Healthy Adrenals
dc.type.content	Doctoral Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	adrenocortical tumors, CYP11A1, 3β-HSD, CYP21, steroidogenic enzymes,
dc.subject.courseuu	Diergeneeskunde