Quantifying naive T cell dynamics in mice using a novel fluorescent division reporter system

dc.rights.license	CC-BY-NC-ND
dc.contributor	Thea Hogan, Benedict Seddon and Andrew J. Yates
dc.contributor.advisor	Externe beoordelaar - External assesor,
dc.contributor.author	Lukas, Eva
dc.date.accessioned	2023-05-31T23:01:11Z
dc.date.available	2023-05-31T23:01:11Z
dc.date.issued	2023
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/43947
dc.description.sponsorship	Utrecht University
dc.language.iso	EN
dc.subject	Lymphocyte dynamics and their potential to self-renew post maturation have frequently been studied using tracking techniques like heavy isotopes. Label is incorporated into newly synthesized DNA during treatment and lost upon cell death. We here introduce a novel method of labeling using yellow fluorescent protein. Upon tamoxifen administration, cells undergoing division as marked by Ki67 transcription induce expression of fluorescence. In contrast to isotope labeling, offspring of fluorescent
dc.title	Quantifying naive T cell dynamics in mice using a novel fluorescent division reporter system
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.courseuu	Bioinformatics and Biocomplexity
dc.thesis.id	11939