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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorBinkhorst, L.
dc.contributor.authorPlanidina, Daria
dc.date.accessioned2023-04-29T00:00:41Z
dc.date.available2023-04-29T00:00:41Z
dc.date.issued2023
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/43825
dc.description.abstractObjective: To study the association between biological sex and tumour necrosis α (TNFα) inhibitor response, to investigate the modifying effects of body mass index (BMI) on TNFα inhibitor treatment response and to study differences in drug survival and reasons to stop anti-TNFα treatment in patients with rheumatoid arthritis (RA). Method: TNFα inhibitor-naive RA patients treated with TNFα inhibitors were included in this retrospective cohort study. The primary endpoint was the difference between Disease Activity Score 28 with CRP (DAS28-CRP) at the start of TNFα inhibitor treatment and after 3-12 months (ΔDAS28-CRP). Multivariable linear regression was used to determine differences in ΔDAS28-CRP. A sub-group analysis based on BMI was done to determine effect modification of BMI on ΔDAS28-CRP. Drug survival was analysed using the log rank test. Differences in reasons to stop TNFα inhibitor treatment was analysed using chi-square. Results: A total of 203 patients, 143 females and 60 males, were included. ΔDAS28-CRP did not differ significantly between the two groups when corrected for lean body mass (LBM) (p = 0,082). This was also the case after stratification (BMI ≥ 30 kg/m2 p = 0,874; BMI < 30 kg/m2 p = 0,096). Differences in drug-survival were not significant (p = 0,236). Differences in reasons to stop anti-TNFα treatment were not significant (p = 0,116). Conclusion: Biological sex seems to not have an association of TNFα inhibitor treatment response in patients with RA. We do however see a trend towards females on average having a worse TNFα inhibitor treatment response than males. This finding can possibly be attributed to a small study population.
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectThe differences in response to TNFalpha inhibitor treatment between male and female patients with RA
dc.titleThe influence of biological sex and body mass index on the response to and duration of TNFα inhibitor treatment in patients with rheumatoid arthritis: a retrospective cohort study
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.courseuuFarmacie
dc.thesis.id16170


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