| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Externe beoordelaar - External assesor, | |
| dc.contributor.author | Zee, Ivar van der | |
| dc.date.accessioned | 2023-04-20T09:22:58Z | |
| dc.date.available | 2023-04-20T09:22:58Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43810 | |
| dc.description.abstract | Objectives: Identify biomolecular mechanisms responsible for acral lentiginous melanoma (ALM) ulceration
and its associated worsened clinical outcomes.
Methods: Transcriptomes of 59 Mexican ALM patients with varying ulceration status were analysed through
the Feature-Engine Python library, which ranked genes based on how much their expression differs between
ulcerated and non-ulcerated tumours. This ranking was analysed through gene set enrichment analysis to
identify biological components.
Results: Multiple proteins that make up desmosomes (a cell-cell adhesion complex) appear downregulated in
ulcerated tumours. The genes PERP and TP63, which are thought to be essential to desmosome formation, also
appear downregulated.
Conclusion: Given the role desmosomes play in both skin integrity and tumour suppression, we hypothesize
them to be the link between ulceration and the associated worsened clinical outcomes. PERP could be involved
in causing their dysregulation. | |
| dc.description.sponsorship | Utrecht University | |
| dc.language.iso | EN | |
| dc.subject | The study aimed to identify biomolecular mechanisms responsible for acral lentiginous melanoma (ALM) ulceration
and its associated worsened clinical outcomes using the transcriptomes of 59 Mexican ALM patients. | |
| dc.title | Ulceration in Mexican Acral Lentiginous Melanoma patients | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.courseuu | Drug Innovation | |
| dc.thesis.id | 15373 | |
