dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Suijkerbuijk, Saskia | |
dc.contributor.author | Groenhof, Josette | |
dc.date.accessioned | 2023-04-04T00:00:43Z | |
dc.date.available | 2023-04-04T00:00:43Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43760 | |
dc.description.abstract | Cell competition is a process that controls tissue quality by mediating cell growth. It plays a role in maintaining homeostasis, embryonic development, tissue repair and was recently established to influence tumorigenesis as well. In this process, neighbouring cells within a tissue compare cellular fitness through both direct and indirect interactions, that result in the elimination of the least fit cell population. As a consequence, the fittest cells remain and take over the tissue, thereby ensuring tissue quality. This review discusses recent insights of cell competition in mammals, shedding a light on the signalling pathways involved in this process and illuminating the role of cell competition as both a tumour-suppressing, and a tumour-promoting mechanism. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | Celcompetitie speelt een rol in het ontstaan en de ontwikkeling van tumoren als zowel een tumor-promotend mechanisme alswel een tumor-suppressend mechanisme. | |
dc.title | Cell competition in homeostasis and during tumorigenesis of mammalian epithelia | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | cell competition; tumorigenesis; mammalian epithelia; Epithelial defence against cancer; relative fitness | |
dc.subject.courseuu | Molecular and Cellular Life Sciences | |
dc.thesis.id | 15478 | |