dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Externe beoordelaar - External assesor, | |
dc.contributor.author | Roodenburg, Rozan | |
dc.date.accessioned | 2023-04-01T00:00:42Z | |
dc.date.available | 2023-04-01T00:00:42Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43739 | |
dc.description.abstract | Purpose: The purposes of this study were to primarily investigate whether determinants measured in adolescence could predict carotid intima-media thickness in adolescents aged 12-16 years. And secondly to determine whether predictors measured in childhood could predict cIMT in adolescents in addition to these measurements in adolescence.
Methods: For this study, data was used from a Dutch birth cohort initiated for the Wheezing Illnesses study Leidsche Rijn, in which healthy children were included at birth and follow-up was obtained until the age of 12-16 years for 232 children. Data from physical measurements combined with questionnaires at the age of 5 and 12-16 was included. With this, univariable and multivariable linear regression analyses were performed for the determinants and predictors separately.
Results: As for the determinants, no statistically significant associations were found with carotid intima-media thickness in adolescence, neither in univariable, nor multivariable linear regression analyses. Regarding the predictors, carotid intima-media thickness in childhood was found to be associated with carotid intima-media thickness in adolescence in univariable linear regression analysis (unstandardized beta 0.337 [95% CI 0.032-0.642]) and multivariable linear regression analysis (unstandardized beta 0.412 [95% CI 0.094-0.729]). The other predictors showed no statistically significant association with cIMT in adolescence.
Conclusion: Carotid intima-media thickness in childhood is found to be a significant predictor for carotid intima-media thickness in adolescence. Apart from this, none of the investigated determinants or predictors showed a significant association with carotid intima-media thickness in adolescence. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | In dit onderzoek heb ik gekeken naar vroeg determinanten van hart- en vaatziekten en hoe deze in verband staan met mogelijke cardiovasculaire predictoren (cIMT en systolische bloeddruk) bij gezonde kinderen en adolescenten. | |
dc.title | Early life determinants of cardiovascular disease | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | cardiovasculair risico, cIMT, early life determinants, systolic blood pressure | |
dc.subject.courseuu | Geneeskunde | |
dc.thesis.id | 12406 | |