dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Koster, E.S. | |
dc.contributor.author | Broxterman, Imke | |
dc.date.accessioned | 2023-03-01T00:00:55Z | |
dc.date.available | 2023-03-01T00:00:55Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43586 | |
dc.description.abstract | Abstract
Background: Adherence rates to antipsychotic drugs in schizophrenia are low, while good adherence is
important for achieving and maintaining remission. In patients with a ‘First Episode of Psychosis’ (FEP),
early medication adherence can influence the further course of the illness. Identification of risk factors for
non-adherence to antipsychotics in patients with an FEP in the first year after remission could prove useful.
Methods: This study was conducted with patients aged 16 to 55 years old, using antipsychotic medication,
and in symptomatic remission of their first psychotic episode for 3-6 months. Medication adherence was
determined with the Medication Possession Ratio (MPR) and validated with self-reported adherence rates.
Covariate adjustment was performed to determine the influence of overlapping prescriptions on the MPR.
The relationship between several patient- and environment-related factors with treatment adherence was
assessed with linear regression.
Results: A total of 260 patients were included in the MPR calculation, of which 88,8% had a good treatment
adherence. The MPR had a very weak correlation with the self-reported adherence rates (p = 0.005). Side
effects (p = 0.013) were positively associated with treatment adherence while patients experiencing more
self-stigma were less adherent (p = 0.030). Overlapping prescriptions accounted for 25% of the variance in
the MPR. After covariate adjustment, only the duration of psychosis was associated with treatment
adherence (p = 0.001).
Conclusion: The MPR is sensitive to prescribing behavior, therefore correction for overlapping
prescriptions is advised. Intervention strategies focused on lowering self-stigma among FEP patients could
improve their adherence rates | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | Risicofactoren voor therapieontrouw onder patiënten met een eerste psychose. | |
dc.title | Predictive factors for antipsychotic treatment adherence among first-episode psychosis
patients in the first year after remission | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | Treatment non-adherence; antipsychotics;FEP;First Episode Psychosis;Schizophrenia;Riskfactors | |
dc.subject.courseuu | Farmacie | |
dc.thesis.id | 11678 | |