dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Heesters, B.A. | |
dc.contributor.author | Hooijschuur, Kevin | |
dc.date.accessioned | 2023-03-01T00:00:36Z | |
dc.date.available | 2023-03-01T00:00:36Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43578 | |
dc.description.abstract | The complement system is one of the earliest defense mechanisms that pathogens encounter. This ancient system consists of a cascade of glycoproteins that leads to cell lysis and labelling of pathogens or compromised host cells for immune response and phagocytosis. Nearly all complement proteins are modified with glycans. Glycosylation is one of the most common, but also one of the most complex protein modifications. Glycans can play major roles in protein folding, protein orientation, kinetics, and activity. While the structures and functions of glycans in the complement system have been studied broadly, many unresolved questions remain. Developments in glycan analysis methods and functional assays gradually improves the knowledge and characterization of complement glycoproteins in the last few years, but further developments will be required to study this system in detail. This review evaluates the current state of the art concerning glycosylation of major complement proteins, and provides a brief introduction on both glycosylation and the complement system. From this broad overview, several complement glycoproteins will be highlighted for their interesting characteristics and functions. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | Glycosylation, the attachment of oligosaccharides to proteins, is one of the most important and complex modifications on proteins and plays a role in many processes and diseases. The complement system is a part of the innate immune system that consists of several tens of proteins, which interact with each other, and with proteins outside the complement system. This review assesses the glycosylation of the complement proteins. | |
dc.title | A Review on the Roles of Potein Glycosylation in Balancing the Complement System | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | Complement system, Glycosylation, Innate immune system, Glycoproteins. | |
dc.subject.courseuu | Drug Innovation | |
dc.thesis.id | 3166 | |