dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Zoete, Marcel de | |
dc.contributor.author | Holtrop, Anne Floor | |
dc.date.accessioned | 2023-02-13T01:00:50Z | |
dc.date.available | 2023-02-13T01:00:50Z | |
dc.date.issued | 2023 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/43533 | |
dc.description.abstract | Intestinal dysbiosis and a dysregulated immune system has been well recognized in the aetiology of inflammatory bowel disease (IBD). However, mechanisms and pathways in-volved remain elusive. Accumulating evidence suggests that bacterial metabolites might greatly impact the immune regulation of the intestine. Butyrate, a short chain fatty ac-ids (SCFA), which is metabolized by the gut bacteria from otherwise indigestible fibre-rich diets, has been shown to ameliorate IBD symptoms. Although the exact mechanisms remain partly understood, it is known that a major drop in butyrate-producing bacteria is associated with the increased pro-inflammatory environment. The increased amount of inflammatory cues facilitate macrophages to differentiate into a pro-inflammatory phenotype. Hence, enhancing butyrate levels in therapy could be a potential treatment for IBD. This review summarised the current knowledge on how butyrate affects intesti-nal macrophages, in terms of recruitment and phenotype polarization. With the inci-dence of IBD outpacing death and global gains in life expectancy, newly diagnosed IBD patients' cases are being added to the pool of prevalent individuals on a continuous ba-sis. Therefore, broadening our knowledge about different pathways is essential for indi-vidualized treatment planning and improving the quality of life of IBD patients. | |
dc.description.sponsorship | Utrecht University | |
dc.language.iso | EN | |
dc.subject | The purpose of this review is to summarize the current understanding of the relationship between butyrate and how alternations of its concentration impacts macrophage functionality within the intestine in the context of IBD. | |
dc.title | Gut microbiome mediated macrophage alterations in the intestine of IBD patients. | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | SCFAs; IBD; Immune cells; Macrophages; Polarization; Dysbiosis | |
dc.subject.courseuu | Molecular and Cellular Life Sciences | |
dc.thesis.id | 13752 | |