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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorGrauw, Janny de
dc.contributor.authorBoessen, Laurens
dc.date.accessioned2022-12-31T00:00:34Z
dc.date.available2022-12-31T00:00:34Z
dc.date.issued2022
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/43361
dc.description.abstractObjectives: To establish the anaesthesia-related (=AR) mortality and morbidity rate, and the factors influencing them, of all horses undergoing standing sedation (for surgical or diagnostic imaging procedures) or undergoing general anaesthesia in a Dutch equine academic teaching hospital. Furthermore, to determine whether the AR mortality and morbidity rates changed during the past years, compared to previous results from the same hospital and to international published figures. Study design: A retrospective observational single-centre study. Research population: In total, 3074 horses anaesthetised or sedated for standing procedures between September 2013 and September 2019. Methods: All patient information and details of the case were retrieved from patient records. This included presence of potential pre-defined risk factors, as well as occurrence of AR morbidities within 7 days post-anaesthesia and AR mortality status at 7 days post-anaesthesia. For various subsets of the population, AR mortality and morbidity rates were determined. Chi-squared tests and Wald tests were used to establish multivariate logistic regression models to analyse potential risk factors associated with overall AR mortality, overall AR morbidity, AR mild trauma, AR myopathy and AR gastro-intestinal morbidities (e.g. post-anaesthetic colic). Results: The combined (surgical and diagnostic procedures under general anaesthesia or during standing sedations) overall (elective and non-elective cases) AR mortality and morbidity rates were 0.8% and 4.8%, respectively. Restricting the analysis to the combined (surgical and diagnostic procedures under general anaesthesia or during standing sedations) elective group solely, percentages decreased to 0.2% and 3.2%, respectively. When the elective group was further restricted to procedures involving general anaesthesia (either surgical cases alone or together with diagnostic cases), the percentages were 0.2% and 3.8%, respectively. For the combined (surgical and diagnostic procedures under general anaesthesia or during standing sedations) non-elective procedures, the percentages are 2.5% and 9.6%, respectively. Multivariate logistic regression models for the combined (surgical and diagnostic procedures under general anaesthesia or during standing sedations) elective group resulted in significant risk factors for the overall AR morbidity and for two of the three most frequent AR morbidities identified in this study (AR mild trauma and AR gastro-intestinal morbidities). Multivariate logistic regression models for the combined (surgical and diagnostic procedures under general anaesthesia or during standing sedations) non-elective group resulted in significant risk factors for the overall AR morbidity and for two of the three most frequent AR morbidities identified in this study (AR mild trauma and AR myopathy). Conclusion: The data suggests a decrease in AR mortality over the past 6 years, compared to both previous data from this clinic and to internationally reported percentages. While AR morbidity may seem to have increased, this is likely due to the different definitions used for some morbidities (especially AR mild trauma) and in this light may actually be lower than the rates previously published by other studies. Further research to refine risk factors (e.g. body condition score instead of body weight) is important so that the AR mortality and morbidity risks can be reduced even further over the coming years. Most importantly, universally accepted definitions of complications and uniform methods to establish outcome need to be drawn up in order for future studies to be less heterogeneous and more directly comparable.
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectThis retrospective observational single-centre study investigates the anaesthesia-related (=AR) mortality and morbidity rate, and the factors influencing them, of all horses (n=3074) undergoing standing sedation (for surgical or diagnostic imaging procedures) or undergoing general anaesthesia in a Dutch equine academic teaching hospital between September 2013 and September 2019.
dc.titleA retrospective analysis of anaesthesia-related morbidity and mortality in horses in a University teaching hospital in the Netherlands
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsanaesthesia; equine; mortality; morbidity; risk; factors; horse
dc.subject.courseuuEquine Health Care
dc.thesis.id862


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