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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorTakken, T
dc.contributor.advisorTrappenburg, JCA
dc.contributor.authorBolkestein, D.A.
dc.date.accessioned2010-02-23T18:00:53Z
dc.date.available2010-02-23
dc.date.available2010-02-23T18:00:53Z
dc.date.issued2010
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/4316
dc.description.abstractBackground: Acute exacerbation in chronic obstructive pulmonary disease (AECOPD) have significant negative impact on patients’ health-status. The bandwidth of day-to-day variability in health-status in patients with stable COPD and impact / amount of change during the event of an AECOPD remains unclear. This study aims at investigating stable day-to-day variability in health-status of patients suffering from chronic obstructive pulmonary disease (COPD) and during an AECOPD. Secondary aim of this study is to investigate the change in health-status during AECOPD. Design: A prospective multi-center cohort study. Methods: Patients (n=40; male=22; FEV1%predicted=60.41 ± 18.67) with a diagnosis of COPD (GOLD I-IV) were asked to record respiratory symptom change during the past 24 hours on a daily diary card. AECOPD was defined using the Anthonisen symptom algorithm. Health-status was measured on three day intervals using the Clinical COPD Questionnaire (CCQ). CCQ scores were retrospectively labeled according to the presence of an AECOPD. Results: Mean follow-up time during the study period was 110.67(± 27,69) days. In total 4427 days (12.13 years) were completed and identified 29 exacerbations (rate:2.39 exacerbations/year). Compared with stable COPD, mean CCQ total score (p=0.004) and the domains function (p=0.009) and symptoms (p=0.000) increased in the event of an AECOPD. There was a clinically and statistically significant impact on health-status directly after AECOPD onset compared with stable periods which was represented in the CCQ total (p<0.001) and domain scores (p<0.05). The maximum deterioration in health-status during AECOPD was beyond day-to-day variations in health-status during stable COPD. Conclusion: This study shows that an AECOPD has major impact on patients’ health-status compared with stable COPD which is beyond day-to-day variability.
dc.description.sponsorshipUtrecht University
dc.format.extent226407 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleImpact of COPD exacerbations
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsCOPD or acute exacerbations or health-status or day-to-day variability
dc.subject.courseuuFysiotherapiewetenschap


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