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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorBardoel, Bart
dc.contributor.authorBakx, Jacco
dc.date.accessioned2022-08-17T00:00:55Z
dc.date.available2022-08-17T00:00:55Z
dc.date.issued2022
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/42320
dc.description.abstractBacteriophages, viruses infecting bacteria, could provide an interesting alternative to antibiotics in the treatment of bacterial infections. However, to be fully usable for treatment their interactions with the microbiome, the innate immune system and the adaptive immune system should be understood. In this review, we set out to map the interactions known in literature. With regards to the microbiome, we show that bacteriophages are numerous in the body and can both protect or disturb the status quo, protecting against foreign invaders but also containing the ability to transform bacteria into more toxic variants. When entering the blood circulation, bacteriophages encounter a variety of factors influencing their longevity, ranging from complement and innate immune cells to antibodies produced by the humoral immune response. Finally, we identify gaps in the current knowledge and propose future research directions
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectIn this review, we set out to map the interactions known in literature between bacteriophages and the microbiome/immune system. We show that bacteriophages are numerous in the body and can both protect or disturb the status quo. In the blood, bacteriophages encounter a variety of factors influencing their longevity, ranging from complement and innate immune cells to antibodies produced by the humoral immune response
dc.titleThe enemy of my enemy is my friend: bacteriophages interaction with the microbiome and immune system
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsbacteriophages; bacteriophage; phage; interaction; immune system; microbiome; therapy;
dc.subject.courseuuInfection and Immunity
dc.thesis.id8646


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