Show simple item record

dc.rights.licenseCC-BY-NC-ND
dc.contributorD. J. L. G. Schutter
dc.contributor.advisorSchutter, Dennis
dc.contributor.authorJansen, Maaike
dc.date.accessioned2022-05-15T00:00:30Z
dc.date.available2022-05-15T00:00:30Z
dc.date.issued2022
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/41564
dc.description.abstractMany reproductive aged women experience symptoms of Premenstrual Syndrome and Premenstrual Dysphoric Disorder. Nonetheless, research on the mechanisms behind these symptoms is limited. In the current paper, it is proposed that the steroid hormone estradiol is associated with these emotional symptoms, using neuroticism scores. In addition, it is expected that estradiol is related to cerebellar white matter volume, and the cerebello-hypothalamic tract (CHT). The CHT is a white matter projection, directly connecting the cerebellum with the hypothalamus. Data from a longitudinal cohort study at Leiden University Medical Centre, the “Braintime” project was used to examine the associations. MRI examinations were performed in twenty subjects, using a 3-tesla 3T unit, and the CHT was exposed using Diffusion Tensor Imaging. The CHT was found unilaterally in 11 cases (nleft = 9 and nright = 2), and bilaterally in 7 cases. However, no significant relations were found between estradiol and neuroticism, estradiol and cerebellar white matter volumes, and cerebellar white matter volumes and neuroticism. Nevertheless, a significant negative correlation was found between the CHT fiber count and white matter volume in cerebellar lobule IV. Furthermore, results showed that participants in which the CHT was found bilaterally scored significantly higher on the NEO-PI-R Depression scale. Hence, further research could examine whether there are significant associations between estradiol, white matter volume, and the CHT, taken age and individual ovulatory phases into account in data collection.
dc.description.sponsorshipUtrecht University
dc.language.isoEN
dc.subjectIn the current paper, it is proposed that the steroid hormone estradiol is associated with these emotional symptoms, using neuroticism scores. In addition, it is expected that estradiol is related to cerebellar white matter volume, and the cerebello-hypothalamic tract (CHT).
dc.titleThe cerebello-hypothalamic tract: The relationship between estradiol, neuroticism, and cerebellar white matter
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsCerebello-hypothalamic tract; cerebellum; white matter; estradiol; neuroticism; Diffusion Tensor Imaging; PMDD
dc.subject.courseuuNeuroscience and Cognition
dc.thesis.id3870


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record