| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Naan, E.C. | |
| dc.contributor.advisor | Galac, S. | |
| dc.contributor.advisor | Kooistra, H.S. | |
| dc.contributor.author | Stals, L. | |
| dc.date.accessioned | 2010-01-11T18:00:08Z | |
| dc.date.available | 2010-01-11 | |
| dc.date.available | 2010-01-11T18:00:08Z | |
| dc.date.issued | 2010 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/4069 | |
| dc.description.abstract | This study focused on cortisol-producing adrenocortical tumors in dogs.
In this project, the presence of somatostatin and dopamine receptors in the healthy and cortisol-secreting adrenocortical tumor of dogs has been studied. We concentrated on determining D1, D2, sst1, sst2, sst3 and sst5. For this purpose, a qPCR technique was used.
The results show that sst1, sst2, sst3 and D2 are all present in normal adrenal tissue and in cortisol-secreting adrenocortical adenomas and carcinomas.
In adenomas, sst1 is significantly down-regulated compared to the control group.
Furthermore, there is a significant up-regulation of sst3 in the tumors compared to the controls. | |
| dc.description.sponsorship | Utrecht University | |
| dc.format.extent | 418304 bytes | |
| dc.format.mimetype | application/msword | |
| dc.language.iso | en | |
| dc.title | Expression of dopamine and somatostatin receptors in healthy adrenal glands and in cortisol-secreting adrenal gland tumors in the dog | |
| dc.type.content | Doctoral Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | cortisol, adrenocortical, tumor, adenoma, carcinoma, cushing, somatostatin, dopamine, receptor. | |
| dc.subject.courseuu | Diergeneeskunde | |
