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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorKummeling, A.
dc.contributor.advisorHunt, G.B.
dc.contributor.authorPeeters, K.
dc.date.accessioned2010-01-05T18:00:55Z
dc.date.available2010-01-05
dc.date.available2010-01-05T18:00:55Z
dc.date.issued2010
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/4063
dc.description.abstractThis study included five dogs with a congenital portosystemic shunt (CPSS), which had surgical attenuation of the shunt. Liver biopsies were taken for Electron Microscopy (EM) evaluation. The evaluation was focussed on the vasculature within the liver. The aspects of the liver samples were described with Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Light Microscopy (LM). The results were compared with liver biopsies of three dogs with normal liver function. In the liver of dogs with a shunt, the endothelial lining of the sinusoids was less porous, more extracellular matrix (ECM) was present, there was steatosis in the hepatocytes and the sinusoids were shorter, in comparison to the normal dog liver. To gain more understanding in why for some dogs surgical attenuation of the shunt leads to development of the liver vasculature and for others not, hepatic tissue should also be studied after the surgery, using the same techniques. Comparing these tissues will give information about differences in liver vasculature before and after surgery.
dc.description.sponsorshipUtrecht University
dc.format.extent3689552 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleEvaluation of the hepatic structure in normal dogs and dogs with congenital portosystemic shunts
dc.type.contentDoctoral Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordscongenital portosystemic shunt, dog, electron microscopy
dc.subject.courseuuDiergeneeskunde


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