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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorSommer, I.
dc.contributor.authorMontagne, D.R.
dc.date.accessioned2009-10-27T18:00:35Z
dc.date.available2009-10-27
dc.date.available2009-10-27T18:00:35Z
dc.date.issued2009
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/3741
dc.description.abstractBackground The relationship between psychoses and epilepsy has been the interest of many studies. Although a large number of these studies give a prevalence rate of psychosis among epileptic patients, to our knowledge this is the first time a meta-analysis is performed on the subject. Aims The aim of this study is to do a meta-analysis to calculate the percentage of psychosis in epilepsy. Also, separate meta-analyses will be performed to study psychosis in primary generalizes epilepsy (PGE) and in temporal lobe epilepsy (TLE). Methods Databases were searched for literature that includes percentages of psychosis in epileptic patients. The meta-analysis is performed with the program Comprehensive Meta-Analysis version 2. Results Seventeen studies were found that met the inclusion criteria. The calculated event rate was 0.042 for overall epilepsy, 0.046 for PGE and 0.10 for the separate meta-analysis that specifically included studies of psychosis in patients with TLE. Conclusion As expected, the percentage of psychosis in TLE was higher than in general epilepsy patients. In conclusion, psychosis appears to be occurring twice as often in epileptic patients than in the general population. Although this is a notable increase, the association between epilepsy and psychosis is not so high as to assume a shared final common pathway.
dc.description.sponsorshipUtrecht University
dc.format.extent104130 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titlePsychosis of Epilepsy: a Meta-analysis
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsMeta-analysis, Psychosis, Epilepsy, Schizophrenia
dc.subject.courseuuBiology of Disease


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