dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Kegel, prof. W.K. | |
dc.contributor.advisor | Roij, prof. R.H.H.G. van | |
dc.contributor.author | Stelt, R. van der | |
dc.date.accessioned | 2016-11-29T18:00:33Z | |
dc.date.available | 2016-11-29T18:00:33Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/24860 | |
dc.description.abstract | Recently it has been shown that genetic regulation in E.Coli can be described by statistical physical models of the transcription factors binding to the DNA.
A similar model for the regulation of genes by allosterically regulated proteins is proposed in this work, using the grand ensemble. This model makes plausible predictions for the expression of such a gene and shows that in theory, such genes can have a steeper response curve than genes regulated otherwise. Then this theory is used to make a quantitative model of the regulation of the lac-operon which also leads to plausible predictions. To compare these predictions to experiments more information about the various binding energies in the problem is necessary. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 34216817 | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | Allosteric switches in transcription regulation | |
dc.type.content | Bachelor Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | biophysics;transcription regulation;lac-operon;grand ensemble; | |
dc.subject.courseuu | Natuur- en Sterrenkunde | |