Show simple item record

dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorKegel, prof. W.K.
dc.contributor.advisorRoij, prof. R.H.H.G. van
dc.contributor.authorStelt, R. van der
dc.date.accessioned2016-11-29T18:00:33Z
dc.date.available2016-11-29T18:00:33Z
dc.date.issued2016
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/24860
dc.description.abstractRecently it has been shown that genetic regulation in E.Coli can be described by statistical physical models of the transcription factors binding to the DNA. A similar model for the regulation of genes by allosterically regulated proteins is proposed in this work, using the grand ensemble. This model makes plausible predictions for the expression of such a gene and shows that in theory, such genes can have a steeper response curve than genes regulated otherwise. Then this theory is used to make a quantitative model of the regulation of the lac-operon which also leads to plausible predictions. To compare these predictions to experiments more information about the various binding energies in the problem is necessary.
dc.description.sponsorshipUtrecht University
dc.format.extent34216817
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleAllosteric switches in transcription regulation
dc.type.contentBachelor Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsbiophysics;transcription regulation;lac-operon;grand ensemble;
dc.subject.courseuuNatuur- en Sterrenkunde


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record