dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Beekman, J. | |
dc.contributor.author | Shaltiël, I.A. | |
dc.date.accessioned | 2009-02-03T18:00:49Z | |
dc.date.available | 2009-02-03 | |
dc.date.available | 2009-02-03T18:00:49Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/2402 | |
dc.description.abstract | Helper T lymphocytes are master regulators of the adaptive immune response. Recent years have
demonstrated the existence of four functionally distinct effector subsets: type 1, type 2, regulatory and IL-17
producing T helper cells. Manipulation of T helper cell differentiation may prove useful for effective vaccine
development and treatment of allergic and autoimmune diseases.
Here, I discuss which signals control T helper cell lineage commitment, how these multiple signals are
integrated during the polarisation process and subsequent cross-regulatory mechanisms that effectuate lineage
stabilisation, affording new insights into the role of T cell receptor-mediated and co-stimulatory signals in T
helper cell polarisation and the role of suppressors of cytokine signalling (SOCS) family members in lineage
stabilisation. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 1335995 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | Getting the message through; signal transduction and integration in T helper cell lineage commitment | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | T helper cell | |
dc.subject.keywords | CD4 | |
dc.subject.keywords | lymphocyte differentiation | |
dc.subject.keywords | polarisation | |
dc.subject.keywords | Th1 | |
dc.subject.keywords | Th2 | |
dc.subject.keywords | regulatory T cell | |
dc.subject.keywords | Foxp3 | |
dc.subject.keywords | T-bet | |
dc.subject.keywords | Gata3 | |
dc.subject.keywords | Rorc | |
dc.subject.courseuu | Immunity and Infection | |