dc.rights.license | CC-BY-NC-ND | |
dc.contributor.advisor | Hoefer, I.E. | |
dc.contributor.author | Willems, S. | |
dc.date.accessioned | 2009-01-29T18:01:34Z | |
dc.date.available | 2009-01-29 | |
dc.date.available | 2009-01-29T18:01:34Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/2385 | |
dc.description.abstract | Arteriogenesis (collateral vessel growth) is triggered by fluid shear stress in case of
an arterial occlusion. It is an important focus in current cardiovascular research as
it might provide new therapeutic opportunities. Although the molecular mechanisms
underlying arteriogenesis are not yet completely understood, it has been shown
that monocytes/macrophages and lymphocytes, in particular NK- and Tlymphocytes,
play an important role in arteriogenesis. The present literature study
was designed to gain more insight into the precise role of the latter cells in the
onset and progression of collateral vessel growth and the interaction between both
cell types. Based on the mechanistically similar process angiogenesis, in which the
inflammatory response has been investigated in more detail, we suggest here that
as a first step in the process of arteriogenesis lymphocytes interact with monocytes
to trigger a cascade of biochemical processes eventually leading to collateral artery
growth. | |
dc.description.sponsorship | Utrecht University | |
dc.format.extent | 443166 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | |
dc.title | The potential role of monocyte-lymphocyte interaction in arteriogenesis | |
dc.type.content | Master Thesis | |
dc.rights.accessrights | Open Access | |
dc.subject.keywords | Arteriogenesis, angiogenesis, monocytes, T-lymphocytes, atherosclerosis, rheumatoid arthritis | |
dc.subject.courseuu | Biology of Disease | |