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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorMaurice, M.M.
dc.contributor.authorGroot, R.E.A. de
dc.date.accessioned2009-01-26T18:03:05Z
dc.date.available2009-01-26
dc.date.available2009-01-26T18:03:05Z
dc.date.issued2009
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/2377
dc.description.abstractThe Wnt signaling pathway is an evolutionary conserved intercellular signaling mechanism. Wnt signaling has many important biological functions, for instance in developmental patterning, stem cell maintenance and tissue regeneration. Aberrant Wnt signaling is implicated in many forms of cancer. Internalization pathways have important functions in many signal transduction pathways. Internalization is also important for Wnt signaling. Endocytosis is essential for Wnt secretion, for the formation of a Wnt gradient and for Wnt signal transduction in the Wnt receiving cell. The role of endocytosis in all steps of Wnt signaling will be discussed in this thesis.
dc.description.sponsorshipUtrecht University
dc.format.extent1140468 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleInternalization, Wnt can't do without
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsCellbiology, signal transduction, vesicular trafficking, clathrin mediated endocytosis, caveolin, morphogen
dc.subject.courseuuCancer Genomics and Developmental Biology


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