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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorTax, C.
dc.contributor.authorTeeuw, J.
dc.date.accessioned2014-09-16T17:00:45Z
dc.date.available2014-09-16T17:00:45Z
dc.date.issued2014
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/18324
dc.description.abstractThe introduction of diffusion tensor imaging fifteen years ago revolutionised the way of studying white matter disorders through the means of diffusion magnetic resonance fibre tractography. It remains the only method available to date to non-invasively study white matter architecture in-vivo. However, there are a number of limitations and pitfalls associated with this technique that calls to question the validity of fibre tractography. In particular the lack of a genuine gold standard prohibits quantitative analysis on the performance of fibre tractography algorithms. It is therefore of great importance for proper validation of fibre tractography to establish robust methods that may serve as a gold standard. In this review, several classical and contemporary methods used to study white matter architecture are discussed that can be used to validate the anatomical trajectory of white matter bundles in the brain derived by fibre tractography with high precision. It emphasises the need for true three-dimensional acquisition of ground truth data at high resolution from realistic specimen in order to accurately resolve the correct trajectory of white matter tracts in the presence of crossing fibres.
dc.description.sponsorshipUtrecht University
dc.format.extent3350049
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleMethods for validating the anatomical trajectory of reconstructed fibre tracts in diffusion magnetic resonance fibre tractography
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsdiffusion magnetic resonance imaging, fibre tractography, validation methods, ground truth, gold standard
dc.subject.courseuuBiomedical Image Sciences


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