Intrinsic neuronal polarity: early events in symmetry breakage and neuronal polarization

Abstract

In this thesis, current knowledge about the formation of the first neurites and their involvement in establishing the polarity of mature neurons will be summarized. In the first chapter, the generation – and the location – of the first neurites will be discussed, with a focus mainly on the initial, instructive polarizing signals. The second chapter will comprise the latest findings and theories on how the cytoskeleton directs neuronal polarity, with an emphasis on the formation of neurites and the elongation of these processes. Finally, the stage 2-3 transition or the formation of the axon will be discussed, as well as the maintenance of the axon.