Endoplasmic Reticulum Stress and lipid metabolism

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Braakman, Ineke
dc.contributor.author	Renne, M.F.
dc.date.accessioned	2014-08-18T17:00:22Z
dc.date.available	2014-08-18T17:00:22Z
dc.date.issued	2014
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/17650
dc.description.abstract	Upon endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) triggers cellular mechanisms to restore ER homeostasis. Aberrancies in lipid homeostasis can cause alterations in biochemical and biophysical properties of the ER membrane, which impair ER function and induce UPR signaling. The UPR is also involved in regulation of lipid metabolism and membrane biogenesis, indicating a link between ER-stress and lipid homeostasis. In this review, we will discuss how alterations in lipid metabolism can activate the UPR, as well as how the UPR alters lipid metabolism to relieve stress from the ER.
dc.description.sponsorship	Utrecht University
dc.language.iso	en
dc.title	Endoplasmic Reticulum Stress and lipid metabolism
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Unfolded protein response, lipid metabolism, endoplasmic reticulum stress, membrane fluidity
dc.subject.courseuu	Molecular and Cellular Life Sciences