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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorCoffer, P.J.
dc.contributor.authorDummer, A.
dc.date.accessioned2014-03-31T17:00:44Z
dc.date.available2014-03-31T17:00:44Z
dc.date.issued2014
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/16460
dc.description.abstractEph receptors and ephrin ligands are the largest family of tyrosine receptor kinases and the receptor and membrane bound ligand can signal to both the receptor and ligand expressing cell. The Eph/ephrin family is involved in many developmental processes and deregulation can result in tumor formation. Especially in breast cancer development, involvement of Eph/ephrin signaling has been demonstrated with in particular EphB4 and ephrinB2 as one of the major players. Moreover, EphB4 and ephrinB2 are also involved in cancer progression towards metastases. However, data for the exact role of EphB4 and ephrinB2 is extremely conflicting. EphB4/ephrinB2 signaling is demonstrated to be involved in tumor suppression via induced adhesion and apoptosis although tumor promoting roles via migration, proliferation, angiogenesis and stem cells has also been demonstrated. In this thesis, current data is discussed and a model is proposed where EphB4 and ephrinB2 can have distinct functions by signaling independent of binding to each other. Moreover, the role of EphB4/ephrinB2 in EMT and cancer stem cell formation and the effect of stromal cells facilitating adhesion of metastatic cells via EphB4/ephrinB2 signaling are discussed. With this model, where independent signaling of both EphB4 or ephrinB2 can promote tumorigenesis and dependent signaling results in tumor suppression, a therapy based on targeting EphB4/ephrinB2 signaling is challenging since a severe side effect might be tumor induction after drug treatment. However, targeting the stromal cells might be effective in blocking adhesion of circulating cells and will provide a therapy in a later stage of cancer.
dc.description.sponsorshipUtrecht University
dc.format.extent9358939
dc.format.mimetypeapplication/zip
dc.language.isoen
dc.titleRole of EphB4/ephrinB2 in breast cancer metastasis
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsEphB4, ephrinB2, breastcancer, metastasis
dc.subject.courseuuCancer Genomics and Developmental Biology


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