The RA signaling pathway in early neural tube development

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Tonk, Ilse
dc.contributor.author	Jansen, R.E.A.
dc.date.accessioned	2013-08-29T17:01:05Z
dc.date.available	2013-08-29
dc.date.available	2013-08-29T17:01:05Z
dc.date.issued	2013
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/14344
dc.description.abstract	In this paper, I reviewed the role of retinoid signaling during neural tube development, the pathway(s) through which RA exerts its effect, with its time and space specific context, and I will propose a set of genes associated with this pathway that may be used to characterize (potential) teratogenic effects of compounds on neural tube development. Additionally, I will give two examples of compounds that are known to interfere with RA signaling and cause neural tube defects and I will propose an AOP for each of these compounds.
dc.description.sponsorship	Utrecht University
dc.format.extent	3540061 bytes
dc.format.mimetype	application/msword
dc.language.iso	en
dc.title	The RA signaling pathway in early neural tube development
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Retinoic acid, neural tube, development, patterning, hindbrain, toxicity, AOP, toxic risk assessment, ethanol, triazoles
dc.subject.courseuu	Cancer Genomics and Developmental Biology