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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorKops, G.
dc.contributor.authorPeeters, J.G.C.
dc.date.accessioned2012-11-20T18:01:09Z
dc.date.available2012-11-20
dc.date.available2012-11-20T18:01:09Z
dc.date.issued2012
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/12014
dc.description.abstractAlterations within the genome, referred to as genetic instability, can occur at the whole chromosome level, i.e. whole chromosomal instability (W-CIN), as well as at the structural DNA level, i.e. genomic instability and structural chromosomal instability (S-CIN). Both types of genetic instability are frequently observed in tumor cells and are causally related to tumor formation. Until recently, it was thought that the mechanisms underlying these two types of genetic instability are distinct and occur independent of each other. However, several recent publications suggest that instability at the whole chromosome level can be a driving force of structural instability. This relationship between W-CIN and structural instability sheds new light on the mechanisms by which W-CIN can contribute to tumorigenesis.
dc.description.sponsorshipUtrecht University
dc.format.extent763407 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleGenetic instability: its causes and its consequences
dc.type.contentMaster Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsWhole chromosomal instability, genomic instability, structural chromosomal instability, cancer, tumorigenesis
dc.subject.courseuuBiology of Disease


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