The coagulation system and its role in bacterial infections.

dc.rights.license	CC-BY-NC-ND
dc.contributor.advisor	Rooijakkers, S.H.M.
dc.contributor.author	Ravesloot, M.M.
dc.date.accessioned	2012-11-01T18:00:48Z
dc.date.available	2012-11-01
dc.date.available	2012-11-01T18:00:48Z
dc.date.issued	2012
dc.identifier.uri	https://studenttheses.uu.nl/handle/20.500.12932/11942
dc.description.abstract	The coagulation system and its inhibitors maintain the hemostatic balance during injury and can modulate the inflammatory response. In addition, the coagulation system is important in host responses to bacterial infections and the local formation of fibrin prevents spread of invading pathogens. However, invasive bacteria are capable of evading this response by stimulating or suppressing the activity of host proteases. This thesis describes some examples of bacterial interactions with different stages of the coagulation system and the results for bacterial dissemination. In addition, recent findings on the role of coagulation in the inflammatory response and the activation of the complement system are discussed.
dc.description.sponsorship	Utrecht University
dc.format.extent	471523 bytes
dc.format.mimetype	application/pdf
dc.language.iso	en_US
dc.title	The coagulation system and its role in bacterial infections.
dc.type.content	Master Thesis
dc.rights.accessrights	Open Access
dc.subject.keywords	Coagulation
dc.subject.keywords	Immune evasion
dc.subject.keywords	Bacteria, Complement
dc.subject.courseuu	Infection and Immunity