| dc.rights.license | CC-BY-NC-ND | |
| dc.contributor.advisor | Geijsen, Dr. N | |
| dc.contributor.author | Kolijn, K. | |
| dc.date.accessioned | 2012-04-27T17:00:44Z | |
| dc.date.available | 2012-04-27 | |
| dc.date.available | 2012-04-27T17:00:44Z | |
| dc.date.issued | 2012 | |
| dc.identifier.uri | https://studenttheses.uu.nl/handle/20.500.12932/10354 | |
| dc.description.abstract | Hematopoietic stem cell (HSCs) therapy in the form of bone marrow transplantations has been used
successfully in the clinic for over 40 years and continues to save lives daily. Clinical stem cell
transplantations are required to reconstitute the hematopoietic system of cancer patients that have
undergone chemotherapy and/or irradiation. Nevertheless, there are still many obstacles with the
clinical use of HSCs, including limited availability of transplantable HSCs, donor matching and graft
versus host reaction and the difficulty to expand HSCs in vitro. Embryonic stem cells (ESCs) and/or
induced pluripotent stem cells (iPSCs) could offer a solution to this problem by providing a means to
generate HSCs in vitro. The knowledge to achieve this will likely come from our understanding of the
origin of HSCs in the embryo. In this review, I will discuss the ontogeny of HSCs and the prospects of
using ESCs and/or iPSCs to generate HSCs. | |
| dc.description.sponsorship | Utrecht University | |
| dc.format.extent | 6053450 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.language.iso | en | |
| dc.title | The origin and future of hematopoietic stem cells | |
| dc.type.content | Master Thesis | |
| dc.rights.accessrights | Open Access | |
| dc.subject.keywords | Hematopoietic stem cells, embryonic stem cells, induced pluripotent stem cells, ontogeny | |
| dc.subject.courseuu | Cancer Genomics and Developmental Biology | |
