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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorHenricks, P.A.J.
dc.contributor.authorHoeve, A.L. ten
dc.date.accessioned2012-03-16T18:01:08Z
dc.date.available2012-03-16
dc.date.available2012-03-16T18:01:08Z
dc.date.issued2012
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/10140
dc.description.abstractTraditionally known as purely an inhibitory neurotransmitter, γ-aminobutyric acid (GABA), its’ receptors and enzymes involved in GABA metabolism and catabolism have been shown to be widely distributed outside the brain and central nervous system. One of the organ systems expressing GABAA and GABAB receptors and other parts of the GABA system is the immune system. GABA and GABA analogous have primarily an inhibitory effect on the immune system, although the effect of activating GABAB receptors seems to be more complex and include immune stimulation. Molecular changes evoked by GABAergic compounds also translate to potential in vivo treatment of diseases associated with the immune system. Activation of immune cells leads in some cases to increased GABAB receptor expression, suggesting a ‘natural’ function of these receptors in immune system functioning.
dc.description.sponsorshipUtrecht University
dc.format.extent1535689 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.titleGABA receptors and the immune system
dc.type.contentBachelor Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsGABA, GABAA, GABAB, immune system, immunology, pharmacology
dc.subject.courseuuBiomedische wetenschappen


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