UU Student Theses Repository: Recent submissions
Now showing items 4721-4740 of 46362
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Superview-1 Remote Sensing for hydromorphological monitoring of shallow water streams within the Water Framework Directive
(2024)Understanding change in river morphology is a crucial aspect to comprehend the complex and intertwined processes within a river ecosystem. The Dutch implementation of the Water Framework Directive (WFD) has established ... -
A Colonization of the Future
(2024)This thesis explores the complex relationship between the mining industry in Kiruna and its implications for the future of indigenous reindeer herders. Kiruna, located in Northern Sweden, is a region renowned for its rich ... -
Transitions in the risk assessment regime: prospects from the case of animal-free testing in the cosmetics industry
(2024)Introduction This thesis examines the transition from animal testing to animal-free methods in risk assessment in the cosmetics industry, specifically focusing on the ban on animal testing in the European sector. It ... -
50 Shades of Sugarcoating: Recent Advances in Convergent Peptide Glycosylation for Homogeneous Glycoprotein Synthesis
(2024)Protein glycosylation is a key post-translational modification that affects protein folding, stability, intracellular trafficking, and protein-protein-interactions. Native glycoprotein biosynthesis is mediated by a diverse ... -
Dose-limiting toxicities due to cisplatin chemoradiotherapy after short hydration schemes in comparison with long hydration schemes in head and neck squamou cell carcinoma
(2024)INTRODUCTION Cisplatin dose-limiting toxicity (CDLT), often due to cisplatin-induced nephrotoxicity, is common during cisplatin-based chemoradiotherapy (CRT) in patients with head and neck squamous cell carcinoma (HNSCC). ... -
Interscapular Pain as Diagnostic Factor for Acute Coronary Syndrome in Males and Females who contact Out-of-Hours Primary Care for Chest Discomfort
(2024)ABSTRACT Background: Telephone triage in family medicine clinics faces challenges in assessing the urgency of patients suspected of acute cardiovascular diseases, e.g. ACS (Acute coronary syndrome). Early diagnosis is ... -
The Impact of Fracture-Related Infection on Quality of Life and Complications
(2024)Abstract BACKGROUND By gaining insight into the Quality of Life (QoL) and occurrence of complications, critical facets in the care for patients with Fracture-Related Infection (FRI) can be mitigated. Therefore, the aims ... -
A Scoping Review. The Value of Urban Bee Research to Urban Planning
(2024)Bees are relevant for several Sustainable Development Goals, most relevant of which is pollination. However, biodiversity rates have dropped sharply over the past decades, in part due to land use change. Contrarily, some ... -
Association of TGF-β and lactate in the induction of regulatory T cells by mesenchymal-CRC organoids
(2024)Regulatory T cells (Treg cells) are a specialized subset of CD4+ T cells with an important role in immune regulation and disease pathogenesis. Treg cells can have an unfavorable effect in the context of cancer by suppressing ... -
The relation of heterozygous BRCA1 and BRCA2 germline variants in the onset of pediatric cancer
(2024)Childhood cancer is a complex and poorly understood process. It is estimated that around 10% of pediatric cancer cases are due to a genetic condition known as a cancer predisposition syndrome (CPS). Variants in adult cancer ... -
Characterizing Sub-Nanometre Fluctuations in Biological and Bio-inspired Materials Using Optical Coherence Tomography
(2024)Optical coherence tomography (OCT) is a non-invasive imaging technique that generates high-resolution cross-sectional tissue images[1]. OCT is very common in ophthalmology and it is part of a group of techniques that ... -
Analysing Anxiety. The Effects of SSRIs on Anxiety-like Behaviour: A Systematic Review & Meta-Analysis
(2024)Abstract: Anxiety disorders are among the largest contributors to the global health related burden. Despite its high occurrence, the cause of anxiety is poorly understood. The serotonergic system appears to play a big role ... -
Ion diffusion in lanthanide-doped nanocrystals
(2024)The unique luminescence of lanthanide-doped nanocrystals has led to numerous scientific and technological applications. Over the last decades, synthesis methods have been developed to produce core/shell nanostructures, ... -
Cas9-Protein Bioconjugation via Click Chemistry to Enhance HDR
(2024)The CRISPR/Cas9 system is a newly-discovered method in gene therapy, showing great potential. However, after the introduction of a double strand break by the Cas9 protein to the genomic DNA, the error-prone non-homologous ... -
A digital twin model for congestion management and market optimization A case-study of industry park Wetering-Haarrijn and Lage Weide in Utrecht, the Netherlands
(2024)The electricity grid is increasingly burdened as energy demand rises and various renewable energy generation technologies are integrated. These technologies become more economically profitable, and so are battery energy ... -
Agreement Between EMA and HTA Organizations About Whether Alternative Treatments Exist and Associations with Relative Effectiveness Assessments
(2024)In Europe, the European Medicines Agency (EMA) and national and regional health technology assessment (HTA) organizations discuss alternative treatments when evaluating a drug. The EMA recommends about marketing authorization ... -
The Effect of Cell Cycle Progression and a Nuclear Localization Signal on CRISPR/Cas9 Gene Correction
(2024)The CRISPR/Cas9 system enables site-specific genome-editing which predominantly occurs via Non-Homologous End Joining (NHEJ), a relatively error-prone pathway. Another pathway is gene correction via Homology Directed Repair ... -
Identification of the Expression Patterns of Fatty Acid Oxidation Genes in a Heterogenic Cardiomyopathy Patient Cohort
(2024)Cardiomyopathy is one of the major causes of heart failure that affects approximately 26 million patients worldwide. In a healthy situation, the heart depends on fatty acid oxidation (FAO) to maintain its energy demand. ...