UU Student Theses Repository: Recent submissions
Now showing items 141-160 of 44243
-
Supporting reasoning skills with heuristic trees in pre-university mathematics
(2024)This research investigates the design of heuristic trees in supporting pre-university students in mathematical reasoning, as well as finding and formulating proofs within Dutch secondary education. The study addresses the ... -
Flip and rule - Exploring ways to test novel Pseudomonas bacteriophage-derived integrases
(2024)In recent years, reducing the environmental impact of various industries has become increasingly important. The genetic engineering* of bacteria can help to meet this need. Engineered bacteria have many sustainable ... -
The Effect of Hyaluronic Acid Coating on Transfection Efficiency and Cytotoxicity of mRNA-Delivering Lipid Nanoparticles on Primary T-cells for CAR T-cell Generation
(2024)Chimeric antigen receptor (CAR) T-cell therapy is a cancer therapy in which a patient’s own T-cells are engineered to express the chimeric antigen receptor, with which they can recognise and kill cancer cells. The therapy ... -
Flow around faults of the West Netherlands Basin in the context of geothermal energy
(2024)Over the past fifteen years, geothermal energy development has increased in the West Netherlands Basin (WNB), both onshore and offshore in the southwest of The Netherlands. Main target reservoirs here for geothermal energy ... -
Activation of Glycolytic Enzymes in Red Blood Cells for Therapeutic Purposes
(2024)Background: Glucose-6-phosphate dehydrogenase (G6PD) is a crucial enzyme in the pentose phosphate pathway and pivotal for maintaining redox balance in red blood cells (RBCs). Deficiency in G6PD can lead to hemolytic anemia, ... -
Guiding macrophages to resolution: insights into the transcriptional pro-resolving mechanisms
(2024)The inflammatory response is a tightly regulated process, which is essential for maintaining immune homeostasis. When this regulation is out of balance, persistence of the inflammatory response can lead to the development ... -
Using a Mouse Model to Study the Role of PBRM1 Loss in the Development of Clear Cell Renal Cell Carcinoma
(2024)A fundamental challenge when studying the evolution and origin of cancer is understanding the early events following oncogenic mutations. In the case of clear cell renal cell carcinoma (ccRCC), the truncal event is the ... -
Calibration of a Landscape Evolution Model in an Alpine Region: on the value of in-situ observations and transferability
(2024)Landscape evolution models (LEMs) are physics-based simulations that evaluate the influence of geomorphic processes on regional landscape development over longer time periods. These processes are represented in a simplified ... -
Predictive literature analysis and in vitro evaluation of Adenine base editors targeting the LMNA-Q493X mutation in murine fibroblasts
(2024)Cardiac laminopathies (LMNA-DCM) are an LMNA-associated subgroup of dilated cardiomyopathy (DCM), and one of the most common types of familial DCM. LMNA is a gene coding for A-type lamins, which are proteins integral to ... -
Various types of Microcredits lead to different success rates: a study in sub-Saharan Africa
(2024)This thesis investigates microcredit programs in Sub-Saharan Africa to discover their determinants of success. Investigating the historical trajectory of microfinance and existing microcredit models, this study identifies ... -
Geopolitical Risk and Bank Profitability: Evidence from European Countries (2013-2023)
(2024)This thesis delves into how geopolitical risk (GPR) affects the profits of banks in the Eurozone, an area known for its unity and political variety. The main question looks at how threats and actions on a geopolitical level ... -
Convergence or Divergence? Comparing the Evolution of SDG Implementation in EU and ASEAN Member States
(2024)This study investigates the longitudinal trajectory of Sustainable Development Goals (SDGs) implementation within the European Union (EU) and the Association of Southeast Asian Nations (ASEAN), exploring the potential for ... -
Octreotide and Delayed Bleeding after Endoscopic Papillectomy: a Propensity Score Matching Analysis
(2024)Background - Endoscopic papillectomy (EP) is widely used for managing ampullary lesions but carries risks of adverse events like delayed bleeding and pancreatitis. Octreotide has been proposed as a preventive measure for ... -
Building a Canine SNP Reference Database: Data Preprocessing and Quality Control Procedures
(2024)Canine genetics play a pivotal role in unraveling the genetic basis of inherited diseases in both dogs and humans. Single-nucleotide polymorphisms (SNPs) are a robust tool for genetic research and with the development of ... -
Exploring the Potential of Generative Machine Learning for Improving Collaboration and Decision-Making of Human Teams
(2024)This study explores the application of Large Language Models (LLM) in collaborative environments, emphasizing the integration of prompt engineering and the "Chain of Thought" method to mitigate hallucination in text ... -
The Role of the Built Environment in the Regenerative Transition
(2024)This research focuses on the environmental impact of cities, proposing a biomimetic approach for urban development. Cities can be redesigned to have a positive impact on the environment if their identity is challenged. For ... -
Waarden, wensen en behoeften van patiënten in de palliatieve zorg: een kwalitatief onderzoek naar de manier waarop zorgverleners in het ziekenhuis hier aandacht voor hebben in hun communicatie met de patiënt
(2024)Context: Het afstemmen van palliatieve zorg op de waarden, wensen en behoeften (WWB) van patiënten is belangrijk. Goede communicatie is het uitgangspunt, maar WWB komen niet altijd voldoende aan bod in de communicatie ... -
Using 3D protein models to uncover genetic risk in ALS
(2024)Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease that is characterized by the involvement of rare genetic variants. Disease association of single rare variants can often not be tested. Therefore, ... -
Clinimetric properties of the CoCo-P: can we really distinguish cognitive functions?
(2024)Background: The Cognitive Complaints – Participation (CoCo-P) identifies cognitive complaints, specifically memory, attention, and executive functioning, as well as fatigue during participation. The CoCo-P seemed appropriate ... -
Designing Nature Positive Cities by applying Ecosystem-level Biomimicry
(2024)The impact of cities, such as biodiversity loss, climate change, and pollution, on local and far away natural ecosystems causes significant concerns within multiple sectors, prompting the need for sustainable solutions and ...