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dc.rights.licenseCC-BY-NC-ND
dc.contributor.advisorEgberink, Herman
dc.contributor.advisorMeer, Frank van der
dc.contributor.advisorGroot, Raoul de
dc.contributor.authorBerne, Anique van
dc.date.accessioned2008-06-09T11:43:40Z
dc.date.available2008-06-09T11:43:40Z
dc.date.issued2008
dc.identifier.urihttps://studenttheses.uu.nl/handle/20.500.12932/9268
dc.description.abstractFeline Infectious Peritonitis (FIP) is a fatal disease in cats caused by a Coronavirus. During FIPv infection the T-cell population is depleted. This is seen in many other diseases, such as measles and AIDS. In these two diseases, the Dendritic Cell (DC) has been shown to play a role in T-cell depletion. This study endeavours to prove if such a mechanism exists in FIP. In order to investigate permissiveness of DCs for FIPv, a growth curve was produced. This growth curve showed prolonged viral reproduction to intermediate titres. As T-cell depletion during FIPv infection occurs at least partly through apoptosis, a TUNEL assay was used to evaluate this. FACS analysis of infected and non-infected co-cultures of DCs with Thymocytes revealed no difference in apoptosis levels. These data suggest that T-cell depletion during FIPv infection does not occur through apoptosis initiated by FIPv-infected DCs.
dc.description.sponsorshipUtrecht University
dc.language.isoen
dc.titleThe role of the Dendritic Cell in the immunobiology of Feline Infectious Peritonitis
dc.type.contentDoctoral Thesis
dc.rights.accessrightsOpen Access
dc.subject.keywordsDendritic Cell
dc.subject.keywordsFIP
dc.subject.keywordsThymocyte
dc.subject.keywordsapoptosis
dc.subject.courseuuResearch Internships Veterinary Medicine


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