Browsing Theses by Subject "Cancer Genomics and Developmental Biology"
Now showing items 1-20 of 104
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A focus on foci: How spatio-temporal regulation of the DNA damage response is crucial for DDR activation and cell fate
(2014)DNA damage is a continuous threat to cells during their lifetime and it can be resolved through activation of the DNA damage response (DDR). This activation is a complicated process which involves the accumulation of a ... -
A role of epithelial-mesenchymal transitions in carcinogenic progression
(2011)The epithelial-mesenchymal transition plays an important role in several developmental processes, tissue repair, but is also associated with fibrosis and cancer. During tumorigenic progression, EMT pathways are used by ... -
Aurora-B kinase as a possible sensor of tension in meiosis.
(2010)Aurora-B kinase is the active subunit of the chromosomal passenger complex (CPC), and is believed to regulate kinetochore-microtubule attachments during mitosis in a tension based manner. With correct allignment of all ... -
Autophagy and Intracellular Pathogens: the Killer, the Victim and the Suspects
(2012)Until recently, autophagy was viewed as a process primarily involved in controlling intracellular biomass as well as protecting cells against toxic protein aggregates and the accumulation of damaged organelles. Recent ... -
BioConductor: Microarray versus Next-Generation Sequencing toolsets
(2014)Both microarray and next generation sequencing platforms generate copious amounts of data for each experiment. Thus, computational tools are required to handle and process such experiments. For microarray analysis, many ... -
Biomarkers in kidney damage
(2011)The aim of this review is to give a comprehensive overview of the current state of biomarkers and biomarker research in kidney damage. Kidneys play an important role in the maintenance of the physiologic balance in the ... -
Biosimilars in the Next Era: Hope or Hype for Biosimilar Monoclonal Antibodies in the Near Future?
(2010)Biosimilars, defined as biological medicinal products comparable in quality, safety and efficacy to reference products, follow the independent regulatory pathway in the EU for marketing authorizations after the patent ... -
BRCA1 breast cancer: metastasis en mouse models
(2012)The BRCA1 gene is a tumour suppressor gene frequently mutated in heritable forms of breast cancers. BRCA1 deficient tumours show a basal-like phenotype. Attempts have been made to model the initial steps of this cancer in ... -
Caenorhabditis elegans: an overview of milestones, genome manipulation techniques and perspectives for the future.
(2011)C. elegans is a well studied animal model and allows researchers to study basic and complex biological processes in a relatively simple multi-cellular environment. However, until recently, researchers did not have the ... -
Cancer Stem Cells
(2010)Review on the Cancer Stem Cells (CSCs) theory. Topics include introduction on the stem cells and CSCs field. Moreover the CSCs are viewed under the blood malignancies and solid tumors (breast, brain, colorectal) classification. -
Caveolae and Cancer, The controversial role of caveolin-1
(2010)More than fifty years ago caveolae were discovered and marked as a new endocytic mechanism. Later it was found that they are formed in microdomains of the plasma membrane, called lipid rafts. The caveolar endocytotic route ... -
Cell Cycle : Runs like "Clock" Work
The circadian clock is the intrinsic timekeeping device that exists within all living organisms and whose function is to integrate information about the light and dark phases of a day into the biological processes that ... -
Cellular polarity: A comparison of animal and plant systems
(2011)All living organisms, from ‘simple’ unicellular prokaryotes to plants and to mammals, show different degrees of spatial organization. In most multicellular organisms, this spatial organization is easily visible. This ... -
Clamping of microtubule attachment sites at the kinetochore: prevention or correction of merotelic attachments?
(2014)The regulation of chromosome segregation is important to insure equal distribution of genetic material between daughter cells. This research proposal will focus on the regulation of chromosome segregation through the ... -
Computational methods for the detection of structural variation in the human genome
(2012)Structural variations are genomic rearrangements that contribute significantly to evolution, natural variation between humans, and are often involved in genetic disorders. Cellular stresses and errors in repair mechanisms ... -
Correction mechanisms of erroneous kinetochore-microtuble attachments in chromosome segregation
(2012)During the process of chromosome segregation the duplicated DNA has to be equally segregated between daughter cells. Only then, proper development of daughter cells is possible. Correct chromsome segregation can only be ... -
CXCR4 and SDF1 are part of the core regulatory mechanism regulating migration of muscle precursor cells to the developing limb
(2011)The ligand CXCR4 and its receptor SDF1 have been associated on several occacions with the formation of the limb musculature, specifically SDF1/CXCR4 signaling has been implicated to be associated with migration of the limb ... -
Database search for yeast vacuolar nucleic acid hydrolases
(2009)The yeast vacuole has an important role in the degradation of cellular material. The vacuole has a low pH that is regulated by H+-ATPases at its limiting membrane that is necessary for the activation of hydrolases involved ... -
Deregulated Aurora B activity and its implications in cancer
(2013)Aurora B kinase, the enzymatic subunit of the chromosomal passenger complex, plays a pivotal role in the regulation of chromosome segregation and cytokinesis. Therefore, Aurora B activity is tightly regulated through ... -
Diabetes, insulin and cancer risk The molecular role of insulin signaling and hyperinsulinemia in cancer development and progression in diabetes patients
(2014)The relationship between diabetes and the risk for cancer development seems to be more and more confirmed. An important link between these two is the hyperinsulinemia found both in patients with T1DM and patients with T2DM. ...