Browsing Theses by Subject "Cancer, Stem Cells and Developmental Biology"
Now showing items 1-20 of 24
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Appropriate Extracellular Matrix (ECM) Mimicking Surfaces Aid In The Establishment Of Serum-Free Cell Culture Media
(2021)Fetal bovine serum (FBS) is very commonly used in cell culture practices as a highly nutrient-rich supplement. The search for alternatives for FBS and the development of chemically defined media is gaining more attraction ... -
BicD2 Controls Cell Cycle-Dependent Positioning of Neural Stem cells
(2022)Radial Glial Progenitors (RGPs) are elongated epithelial cells and are the primary progenitor cell during development of the mammalian neocortex. The RGP cell-cycle and nuclear migration within the ventricular zone (VZ) ... -
Ethical considerations relating to different types of heart valve prosthetics
(2022)With the increasing global population and average lifespan more people suffer from age associated diseases such as cardiovascular disease. In some cases the disease can be treated with novel medical devices such as pacemakers ... -
Everything should be linked: linking and visualising data for dynamic multidimensional biological data interpretation.
(2015)To date, studies on non-coding regions of the genome, specifically in cancer, have been limited. This is mainly due to the complex nature of putative functional elements in these regions. In parallel with the ENCODE-project, ... -
Expanding the genetic toolbox to explore redox signalling
(2021)Over the last decade, the importance of redox signalling and reactive oxygen species (ROS) for maintaining physiological signal transduction have been discovered. ROS, and in particular hydrogen peroxide (H2O2), have ... -
Exploring the ribosomal stress pathway as a targetable vulnerability in TP53 aberrant Acute Lymphoblastic leukemia
(2023)Acute Lymphoblastic Leukemia (ALL) is one of the most frequently diagnosed cancers in children. Although the survival rates have been increasing, relapses are still occurring, which are generally hard to cure. Especially ... -
Genomic structural variations and their role in carcinogenesis
(2022)Rearrangements of the genome known as structural variations (SVs) that amplify, delete or reorder chromosomal material are an important source of genomic diversity across humans. Nowadays, with the recent improvements of ... -
Long-term machine perfusion: a new tool in the box to increase available liver grafts
(2022)Liver diseases are becoming more prevalent in the western world. At this moment, the only viable therapy for end-stage liver diseases is liver transplantation. Liver transplantation, as first successfully performed by Dr ... -
mRNA features that guide translational control
(2022)Features encoded in the mRNA contribute substantially to the translation efficiency of a transcript. After processing of the 5’ and 3’ end and export of the mRNA to the cytoplasm, translation is initiated via a cap-dependent ... -
Obesity and breast cancer: Linking inflammation to aromatase activity in cancer progression and therapy resistance
(2022)Breast cancer affects an increasing number of women every year, and a major risk factor for this disease is obesity. I studied the connection between breast cancer progression and an obese microenvironment in ER+ breast ... -
Opportunities for Single-Cell Approaches in Cancer Epigenomics
(2022)Epigenetic alterations are reversible modifications that alter the way gene expression is regulated without changing the underlying DNA sequence. They play a key role in both healthy development, as well as in diseases ... -
Pediatric glioblastoma multiforme (GBM) models for immunotherapy testing: Incorporating models of the tumour immune microenvironment and the blood-brain-barrier (BBB).
(2023)Pediatric Glioblastoma Multiforme (GBM), while not as common as adult GBM, exhibits poor prognosis despite the application of many conventional cancer treatment approaches. Cancer immunotherapy, including cancer vaccines, ... -
Resistance Mechanisms to HER2-Targeted Therapy in Gastroesophageal Carcinoma: A Systematic Review
(2022)Ieder jaar wordt er bij meer dan één miljoen mensen maag- of slokdarmkanker gediagnostiseerd. Voor beide ziektes zijn er meerdere subtypes beschreven die in verschillende werelddelen voorkomen. In Westerse landen komt ... -
Signature SBS7a in pediatric BCP-ALL
(2023)Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in the Netherlands, with an incidence of around 115 new cases per year. Although the survival rates have reached 90%, the underlying mutational ... -
Studying the tumor microenvironment of Hodgkin Lymphoma with scRNA-seq
(2022)The treatment of Hodgkin lymphoma (HL) is considered a success story: cure rates surpass 80%. However, the successful treatment of HL can result in adverse side-effects later in life. Thus, there remains a need for novel ... -
The history and future perspectives of anti-angiogenics
(2021)Angiogenesis is the process of formation of new blood vessels from existing ones and it is involved in both physiological and pathological conditions. In 1971, Dr. Folkman hypothesized that for tumour development, an ... -
The role of epigenetic inheritance in the maintenance or alteration of cellular identity
(2022)Cell identity is tightly regulated by cell-specific expression patterns. This is caused by epigenetic factors that pack the DNA into chromatin, making it accessible or inaccessible to transcription machinery. The regulation ...